Expression of PGK1 by Prostate Cancer Cells Induces Bone Formation

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Expression of PGK1 by prostate cancer cells induces bone formation.

Prostate cancer (PCa) is one of the solid tumors that metastasize to the bone. Once there, the phenotype of the bone lesions is dependent upon the balance between osteoblastogenesis and osteoclastogenesis. We previously reported that overexpression of phosphoglycerate kinase 1 (PGK1) in PCa cell lines enhanced bone formation at the metastatic site in vivo. Here, the role of PGK1 in the bone for...

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ژورنال

عنوان ژورنال: Molecular Cancer Research

سال: 2009

ISSN: 1541-7786,1557-3125

DOI: 10.1158/1541-7786.mcr-09-0072